P2: Muscle and fat tissue wasting in patients with chronic heart failure: the impact of impaired insulin sensitivity
Wolfram Doehner and Stefan Anker
Summary
In advanced chronic heart failure (CHF), severe tissue wasting
(i.e. cachexia) occurs, resulting from an overall anabolic failure and a catabolic / anabolic imbalance. Cardiac cachexia represents a serious complication of CHF associated with major pathophysiological alterations, increased morbidity, and a very poor prognosis. CHF represents a major medical and socio-economic burden of modern society with epidemic growth. As a matter of fact, CHF carries a worse prognosis than most malignant diseases. Despite substantial advances in the medical therapy of CHF, to date no therapeutic option has been developed to attenuate or even reverse the wasting process.
Wolfram Döhner, MD, PhD
Training: |
University Medical School Leipzig, Germany |
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Prev. appoin.: |
House Officer at Charité, Franz Volhard Klinik of Molecular Cardiology, Berlin; Physician and PhD Student at Royal Brompton Hospital/National Heart & Lung Institute, London, UK |
Current position: |
House Officer at Charité, Franz Volhard Klinik of Molecular Cardiology, Berlin; Physician and PhD Student at Royal Brompton Hospital/National Heart & Lung Institute, London, UK |
Publications relevant to the Project
Doehner W, Rauchhaus M, Ponikowski P, Godsland IF, von Haehling S, Okonko DO, Leyva F, Proudler AJ, Coats AJ, Anker SD. 2005. Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure. J Am Coll Cardiol. Sep;46:1019-1026.
